SCREEN-WELL生物活性脂質(zhì)庫包含190種96孔格式的生物活性脂質(zhì)。非常適合篩選或鑒定重組孤兒G蛋白偶聯(lián)受體、靶標(biāo)驗(yàn)證、二次篩選、驗(yàn)證新測(cè)定和常規(guī)藥理學(xué)應(yīng)用。
【資料圖】
The SCREEN-WELL? Bioactive Lipid Library contains 190 bioactive lipids in a 96 well format. Ideal for screening or identifiying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays and for routine pharmacological applications.
Applications:HTS
Contents:190 compounds including: Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids.
Quantity:100 or 500μl per well.
Concentration:DMSO solutions (1.0 or 0.1mM, depending on compound).
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
Long Term Storage:-80°C
SCREEN-WELL生物活性脂質(zhì)庫#BML-2800-0100相關(guān)參數(shù)說明：
內(nèi)容：190種化合物，包括：激動(dòng)劑和拮抗劑，內(nèi)源性大麻素，法呢基/香葉基香葉基衍生物，HETEs deHETEs，七氧西林，多不飽和脂肪酸，白三烯，脂氧素，LPA和磷脂酸，十八烷類，PAF，前列腺素和血栓素，類維生素A，維生素D代謝物，鞘脂。
數(shù)量：每孔100或500μl。
濃度：DMSO溶液（1.0或0.1mM，取決于化合物）。
使用/穩(wěn)定性：在-80°C下儲(chǔ)存時(shí)，自收到之日起至少可穩(wěn)定一年。
航運(yùn)：干冰
長(zhǎng)期儲(chǔ)存：-80°C
RUO -僅供研究使用
SCREEN-WELL生物活性脂質(zhì)庫部分文獻(xiàn)參考：
1.Molecular basis for the interaction of cellular retinol-binding protein 2 (CRBP2) with non-retinoid ligands: J. Silvaroli, et al.; J. Lipid Res. 62, 100054 (2021),
2.Mechanism of activation for the sirtuin 6 protein deacylase: M.A. Klein, et al.; J. Biol. Chem. 295, 1385 (2020),
3.Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1: J.A. Silvaroli, et al.; ACS Chem. Biol. 14, 434 (2019),
4.Brown Adipogenic Reprogramming Induced by a Small Molecule: B. Nie, et al.; Cell Rep. 18, 624 (2017),
5.Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest. 127, 2739 (2017),
6.AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells: T. Yoshinaga, et al.; PLoS One 11, e0167848 (2016),
7.Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells: J.H. Rhim, et al.; Sci. Rep. 6, 26547 (2016),
8.Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans: P.R. Rodrigues, et al.; G3 (Bethesda) 6, 1695 (2016),
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